Table 1 Information components (IC) calculated for CAR-T therapy (ND = 5,576) for the given adverse reactions
From: Cardiotoxic profiles of CAR-T therapy and bispecific T-cell engagers in hematological cancers
Reaction Name | NA | NAD | IC | IC025 |
|---|---|---|---|---|
Inflammatory/Effusive Events | ||||
C-Reactive Protein Increased | 25,169 | 70 | 3.769 | 3.372 |
Capillary Leak Syndrome | 1206 | 14 | 4.324 | 3.421 |
Myocarditis | 28,484 | 2 | −1.211 | −3.804 |
Pericarditis | 21,552 | 3 | −0.363 | −2.432 |
Pericardial Effusion | 17,867 | 18 | 2.277 | 1.485 |
Cardiac Tamponade | 2,897 | 0 | −1.053 | −11.377 |
Arrhythmic Events | ||||
Tachycardia | 202,122 | 174 | 2.198 | 1.948 |
Atrial Fibrillation | 79,948 | 45 | 1.569 | 1.073 |
Atrial Flutter | 6773 | 8 | 2.274 | 1.062 |
Electrocardiogram QT Prolonged | 27,465 | 9 | 0.763 | −0.376 |
Ventricular Tachycardia/Ventricular Fibrillation | 27,573 | 15 | 1.464 | 0.593 |
Cardiac Arrest | 75,180 | 31 | 1.124 | 0.524 |
Hemodynamic Events | ||||
Hypotension | 268,722 | 469 | 3.220 | 3.068 |
Sinus Tachycardia | 14,075 | 18 | 2.571 | 1.779 |
Cardiomyopathy-Related Events | ||||
Stress Cardiomyopathy | 2700 | 6 | 2.699 | 1.284 |
Ejection Fraction Decreased | 10,708 | 11 | 2.209 | 1.184 |
Cardiac Failure | 130,976 | 30 | 0.241 | −0.369 |
Cardiogenic Shock | 7138 | 5 | 1.592 | 0.029 |
