Fig. 2: Topological Data Analysis of the combined global sepsis cohort.
From: Sepsis endotypes identified by host gene expression across global cohorts
The normalized expression of the top 1000 genes from 506 subjects was used to perform Topological Data Analysis (TDA). This decomposition method groups patients based on their gene expression profiles and produces a relationship network consisting of nodes (clusters of patients with similar gene expression) and edges (one or more patients are shared between two adjacent nodes). a The sepsis TDA network was divided into four groups along a left-to-right axis, which corresponded to differences in 28-day (d28) mortality. The TDA network was colored by 28-day mortality on a continuous scale ranging from green (0% of patients in the node died) to red (40% or more of patients in the node died). b Patients were stratified into three high-mortality groups (t1, t2, t3) and one low-mortality group (t4-5) (yellow - highlights TDA subgroup; red – indicates mortality).
