Fig. 3: The functional pathway and relationships of CML module and drug modules in the human interactome.
From: A network-based trans-omics approach for predicting synergistic drug combinations
a Enriched functional pathways in the CML module, and the capsaicin and mitoxantrone modules in the method with network propagation (SyndrumNET). Purple color indicates CML. Light green color indicates capsaicin. Yellow color indicates mitoxantrone. The p-value calculated by Fisher exact test using clusterProfiler46. The sample number is 8,772 genes. The size of points reflects the p-value of the enrichment analysis. b Distribution of the coverage of enriched pathways between the CML module and drug modules. Vertical axis indicates coverage of the functional pathways by drug module pairs. Horizontal axis indicates rank of the drug module pairs when sorted in order of the coverage. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; white points, mean; black points, outliers. c Network-based relationship between the CML module and a synergistic drug combination, capsaicin and mitoxantrone, in the chronic myeloid leukemia pathway (hsa05220). Purple-colored nodes indicate CML module genes. Green-colored nodes indicate capsaicin module genes and orange-colored nodes represent mitoxantrone module genes. Aqua-colored nodes indicate clopamide module genes. The purple edged nodes indicate that the gene belongs to the CML module. The purple color edges show the interaction between the genes in the CML module. Green and orange color edges represent the interaction between the module genes of capsaicin and mitoxantrone, respectively.
