Table 3 The enriched functional pathways in the DEGs
From: A network-based trans-omics approach for predicting synergistic drug combinations
class | Capsaicin | Mitoxantrone | Combination | Pathways |
|---|---|---|---|---|
I | ✓ | ✓ | ✓ | hsa05202:Transcriptional misregulation in cancer |
II | ✓ | ✓ | hsa04060:Cytokine-cytokine receptor interaction, hsa04061:Viral protein interaction with cytokine and cytokine receptor, hsa04151:PI3K-Akt signaling pathway, hsa04630:JAK-STAT signaling pathway, hsa05144:Malaria, hsa04510:Focal adhesion | |
III | ✓ | ✓ | hsa05322:Systemic lupus erythematosus, hsa04613:Neutrophil extracellular trap formation, hsa05034:Alcoholism, hsa05203:Viral carcinogenesis, hsa04217:Necroptosis | |
IV | ✓ | hsa04964:Proximal tubule bicarbonate reclamation, hsa05200:Pathways in cancer, hsa05219:Bladder cancer, hsa05224:Breast cancer, hsa04911:Insulin secretion, hsa04015:Rap1 signaling pathway, hsa04961:Endocrine and other factor-regulated calcium reabsorption, hsa00410:beta-Alanine metabolism, hsa04972:Pancreatic secretion, hsa04974:Protein digestion and absorption, hsa00910:Nitrogen metabolism, hsa04014:Ras signaling pathway | ||
V | ✓ | hsa04940:Type I diabetes mellitus, hsa04917:Prolactin signaling pathway, hsa04668:TNF signaling pathway, hsa05323:Rheumatoid arthritis, hsa04913:Ovarian steroidogenesis, hsa05150:Staphylococcus aureus infection, hsa00650:Butanoate metabolism, hsa04080:Neuroactive ligand-receptor interaction, hsa04610:Complement and coagulation cascades, hsa00830:Retinol metabolism | ||
VI | ✓ | hsa04929:GnRH secretion, hsa04024:cAMP signaling pathway, hsa04064:NF-kappa B signaling pathway, hsa05217:Basal cell carcinoma |
