Table 1 IC50 values of T3, GC-1, and ZTA-261

From: Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261

Competitor

THRα

THRβ

IC50 (nM)

95% CI (nM)

IC50 (nM)

95% CI (nM)

T3

3.4

1.8–6.5

3.6

3.0–4.3

GC-1

73

53–97

3.4

2.6–4.3

ZTA-261

6.6 × 102

3.4 × 102–1.2 × 103

6.3

4.8–8.3

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