Fig. 2: Important role of direct tumor-adipocyte interaction. | Communications Medicine

Fig. 2: Important role of direct tumor-adipocyte interaction.

From: Converging deep learning and human-observed tumor-adipocyte interaction as a biomarker in colorectal cancer

Fig. 2

a As TAF is characterized by the proximity of tumor cells and adipocytes, but not necessarily the direct contact between tumor cells and adipocytes, there were also SARIFA-negative CRCs displaying TAF (32.6%) in our pathologic review. b Presence of TAF was not significantly associated with poorer outcomes in SARIFA-negative CRC in TCGA cohorts COAD and READ (each p > 0.05), which potentially indicates the important role of a direct tumor-adipocyte interaction. Upper panel: overall survival, middle panel: disease-specific survival, lower panel: progression-free survival. For each microscopic image appropriate scale bars are provided; scale bars indicate 200 µm. COAD colonic adenocarcinoma, CRC colorectal cancer, NOS not otherwise specified, TAF tumor adipose feature, TCGA The-Cancer-Genome-Atlas, SARIFA Stroma AReactive Invasion Front Area, READ: rectal adenocarcinoma.

Back to article page