Fig. 1: Individual history and family history, including parents, same-sex twins, and full siblings, of psychiatric disorders and the risk of gastrointestinal disorders.

a schizophrenia (SCZ). b Bipolar disorder (BPD). c Major depressive disorder (MDD). d Obsessive-compulsive disorder (OCD). Odds ratio and 95% confidence interval represents the association estimated in the within-individual analyses and in within-family analysis of different types of relatives. Green triangle indicates peptic ulcer disease (PUD), orange diamond indicates gastroesophageal reflux disease (GERD), blue square indicates irritable bowel syndrome (IBS), and pink circle indicates inflammatory bowel disease (IBD). The sample size for analyses of individual history and parental history = 4,504,612, same-sex twins = 51,664, and full siblings = 3,322,959.