Fig. 1: N-glycan heterogeneity in HCC tissue.
From: Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma
a–j H&E stain of ten individual tissue sections with the pathology annotated cancer lesion highlighted, along with four MALDI imaging images showing specific alterations in N-linked glycosylation. M/Z values are given above or below each image. a–e Five individual tissues with predominantly changes in fucosylation; f–j Five individual tissues with changes in branching but not fucosylation. k Heat map showing N-glycan clusters in different patient groups. l Correlation plot showing that N-glycan alteration occurs in clusters. a–j Color scale is used to represent the intensity of spectra, with blue being the weakest and red being the strongest. k–l, the color and size scale and associated with each panel is indicated.
