Table 2 Patients used for biomarker analysis

Number

100

101

NA

Gender(M:F)%^c

71:29

65:36

0.3920

Age (years with range)^d

65(42–93)

56 (18–79)

<0.0001

Ethnicity (% Non-Hispanic White/African-American/Hispanic/Asian/Other)^e

39/2/42/15/2

51/4/37/5/4

0.0830

BCLC Stage (0, A, B, C)^f

2/39/46/13

-

NA

Etiology% (HCV/HBV/Alcohol/NAFLD/other)^g

48/5/12/8/27

26/2/29/10/34

0.0031

AST (IU/mL)^h Mean (range)

82.1 (11–325)

55.4 (12–207)

0.0002

ALT(IU/mL)ⁱ Mean (range)

59.4 (5–633)

40.7 (52–80)

0.0010

ALK (IU/ML)^j Mean (range)

155.7 (40–347)

132.3(43–1120)

<0.0001

Albumin (g/dL)^k Mean (range)

3.4 (1.7–4.9)

3.8 (2.4–4.8)

<0.0001

AFP (ng)^l Mean (range)

454.7 (3–9972)

8.9 (3–192)

<0.0001

AFP AUROC^m

<0.0001

AFP-L3 (%)ⁿ Mean (range)

20.9 (0.5–90)

5.4 (0.5–12.6)

<0.0001

AFP-L3 AUROC^o

<0.0001