Fig. 1: Development of cell type-specific functionally enriched DNA methylation (DNAme) aging clocks. | Communications Medicine

Fig. 1: Development of cell type-specific functionally enriched DNA methylation (DNAme) aging clocks.

From: Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer

Fig. 1

a Age-related DNAme changes may be elicited, amongst other factors, by the overall aging process, cell type-specific processes, functional changes relating to aging, and the interplay between these three aspects. Here, we aimed to develop functionally enriched DNAme signatures indicative of one or more of these aspects by identifying overlapping CpGs, and evaluated these signatures in a variety of contexts. Discovery sets are annotated in Supplementary Data 1. b Overlaps utilized for development of CpG signatures. Icons from Biorender.com.

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