Table 3 Pathways involved in the last weeks of life

From: Urinary metabolite model to predict the dying process in lung cancer patients

Pathways involved in the last weeks of life

Energy metabolism

Disrupted mitochondrial fatty acid β-oxidation

Mitochondrial dysfunction

Decreased RNA synthesis

Decreased protein synthesis

Altered 1-carbon metabolism

Altered nucleoside (purine, pyrimidine) synthesis

Muscle loss/damage

Oxidative stress

Cell membrane breakdown / turnover

Altered hormone production

Altered amino acid metabolism

Kynurenine pathway activation

Decreased oral intake

  1. This table is a summary of all the metabolites identified as changed significantly from the volcano plot analysis and ANOVA analysis of the Training dataset. Further information to support this table is in Supplementary Data File 4.
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