Fig. 5: Subgroup analysis of various influencing factors on LVEF following ECM treatment. | Communications Medicine

Fig. 5: Subgroup analysis of various influencing factors on LVEF following ECM treatment.

From: Preclinical extracellular matrix-based treatment strategies for myocardial infarction: a systematic review and meta-analysis

Fig. 5

a Subgroup analysis showing pooled estimates (black symbols) per stratum for the variables species, sex, disease model, ECM source, method of ECM administration and timing of ECM treatment [Early (< 1day post-MI), Mid ( = 1-7days post-MI), Late (> 7days post-MI)]. The overall pooled mean difference (MD) from a random effects model, is shown by a red dotted line and a diamond (respectively). Error bars represent 95% confidence interval (CI). N represents the number of experiments within each subgroup. b Meta-regression timing of outcome measurement and (c) ECM dose. NR not reported, MI myocardial infarction, IR ischemia reperfusion, ECM extracellular matrix, dECM decellularized extracellular matrix.

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