Table 2 Summary of Findings

Outcomes	No. of studies (animals)	Pooled effect [95% CI]	Risk of Bias	Inconsistency	Indirectness	Imprecision	Publication Bias	Certainty of the evidence (GRADE)
LVEF	60 studies (1292 animals)	MD 10.9% [8.7%; 13.0%]	Downgrade	Downgrade	No Effect	No Effect	No Effect	⊕⊕⊕○ Moderate^a
FS	38 studies (708 animals)	MD 8.2% [5.6%; 10.9%]	Downgrade	Downgrade	No Effect	No Effect	No Effect	⊕⊕⊕○ Moderate^a
Stroke Volume	12 studies (225 animals)	SMD 0.6 [0.2; 1.0]	Downgrade	Downgrade	No Effect	Downgrade	No Effect	⊕○○○ Very Low^b
Infarct Size	52 studies (866 animals)	MD -11.7% [-14.7%; -8.6%]	Downgrade	Downgrade	No Effect	No Effect	No Effect	⊕⊕⊕○ Moderate^a
Wall Thickness	30 studies (758 animals)	SMD 1.2 [0.9; 1.5]	Downgrade	Downgrade	No Effect	No Effect	Downgrade	⊕⊕○○ Low^c

^aModerate quality of evidence is due to unknown/unclear risk of bias and serious inconsistency.
^bLow quality of evidence is due to unknown/unclear risk of bias, serious inconsistency and imprecision.
^cLow quality of evidence is due to unknown/unclear risk of bias, serious inconsistency and publication bias.
LVEF left ventricular ejection fraction, FS fractional shortening, MD mean difference, SMD standardized mean difference, CI confidence interval.

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