Fig. 2: Enrichment for various genomic annotations. | Communications Medicine

Fig. 2: Enrichment for various genomic annotations.

From: Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries

Fig. 2

For each disorder we plot the enrichment when genomic annotations are used instead of 0 or 1 any-gene pairing. Each dot is the beta and CI’s for that beta. Abs absolute value or that the absolute value of SNP effect sizes was used, CADD combined annotation dependent depletion, pLI loss intolerance probability score. When points are missing from the plot, it is because no Exonic variant was a drug target after pruning SNPs for linkage disequilibrium. MDD major depressive disorder, SUD Substance use disorders.

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