Fig. 1: 35-year timeline depicting major historical events in the development of in silico variant pathogenicity prediction tools (VPPTs). | Communications Medicine

Fig. 1: 35-year timeline depicting major historical events in the development of in silico variant pathogenicity prediction tools (VPPTs).

From: Evaluating variant pathogenicity prediction tools to establish African inclusive guidelines for germline genetic testing

Fig. 1

Major historical events by timelines shaping VPPT development and defined as 1990-2000 (Genomic Era Begins), 2000–2010 (First Generation of VPPTs), 2010–2015 (Early Machine Learning) and 2015–current (Contemporary Machine Learning).

Back to article page