Table 1 Demographic and clinicopathological characteristics and benchmark (positive and negative) datasets by genetic ancestry
African | European | ||
|---|---|---|---|
Total (n) | 50 | 50 | |
Country of origin (n) | South Africa (50) | Australia (49), South Africa (1) | |
Genetic ancestral fraction% (n) | >99% (50) | >99% (47), 97% (1), 90% (1), 74% (1) | |
Mean age (range) years | 69.0 (53–99) | 62.4 (50–72) | |
Mean PSA (range) ng/mL | 448.3 (8.21–4841) | 12.8 (3.5–31.8) | |
ISUP grade (n) | 3 | 0 | 1 |
4 | 12 | 10 | |
5 | 38 | 39 | |
Positive dataset (n) | ClinVar | 39 | 99 |
InterVara | 135 | 146 | |
Merged | 158 | 202 | |
Negative dataset (n) | ClinVar | 15,272 | 21,356 |
InterVara | 32,922 | 93,003 | |
Merged | 41,045 | 103,886 | |
