Fig. 5: Effects of miR-15a modulation in hAoSMCs on gene-sets of relevance to human AAA pathology. | Communications Medicine

Fig. 5: Effects of miR-15a modulation in hAoSMCs on gene-sets of relevance to human AAA pathology.

From: MicroRNA-15a-5p mediates abdominal aortic aneurysm progression and serves as a potential diagnostic and prognostic circulating biomarker

Fig. 5

A Ridge plot of GSEA analysis results using MSigDB-H (hallmark) gene-sets. B Fold change plot showing genes significantly down-regulated (FDR < 0.05, fold change (log2) < 0) in hAoSMCs treated with miR-15a-mimic and significantly up-regulated (FDR < 0.05, fold change (log2) > 0) in hAoSMCs treated with miR-15a-inhibitor. Highlighted in blue are predicted miR-15a targets (present in DIANA or miRDB), in green experimentally confirmed miR-15a targets (present in miRTarBase). Labeled are top 10 differentially regulated genes with largest difference in expression between miR-15a-inhibitor and mimic treatments. C Data as in (B), only genes also down-regulated in human AAA datasets are shown. D Bar plot showing regulation of genes in C in AAA datasets (left side) and miR-15a-modulated hAoSMCs (right side; fold change between miR-15a-inhibitor and mimic treatments). Genes labels are colored in same colors as highlighted genes in (B). E Ridge plot of GSEA analysis results in manually selected DisGeNET gene-sets of relevant diseases.

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