Fig. 6: miR-15a is involved in regulation of known mechanisms in AAA pathogenesis and its circulating levels are dysregulated among AAA patients. | Communications Medicine

Fig. 6: miR-15a is involved in regulation of known mechanisms in AAA pathogenesis and its circulating levels are dysregulated among AAA patients.

From: MicroRNA-15a-5p mediates abdominal aortic aneurysm progression and serves as a potential diagnostic and prognostic circulating biomarker

Fig. 6

Biofluids from multiple cohorts of AAA patients were analyzed, discovering differences in expression of miR-15a and thus revealing a biomarker with potential diagnostic implications, but also shown to be concentrated in diseased areas. miR-15a has been described to play a role in the fate of aortic smooth muscle and endothelial cells. Our studies in a mouse AAA model show that its inhibition can limit growth of experimentally induced aortic aneurysms. Created in BioRender (https://BioRender.com/pg73t6h).

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