Fig. 2: Sequential immunization with clonally related Envs.
From: Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques
a NHP immunization scheme (see methods and ref. 9). TF transmitted founder. b, c Cross-reactivity of B cells with non-stabilized gp140 Envs immunogens (outer ring) and stabilized CH505.w136 SOSIP trimer (inner ring) (b) before and (c) after CH505.w136 SOSIP trimer immunizations. Data are shown as aggregate (“All NHPs”) and for each NHP. Number of B cells analyzed is shown for each chart. Reactivity with individual and multiple non-stabilized and SOSIP stabilized gp140 Env immunogens is color coded as follows: gray: no reactivity with non-stabilized gp140 Envs (0 gp140); yellow: reactivity with one non-stabilized gp140 Env; orange: reactivity with two non-stabilized gp140 Envs; red: reactivity with three non-stabilized gp140 Envs; brown: reactivity with four non-stabilized gp140 Envs; white: no reactivity with SOSIP-stabilized gp140 Env; green: reactivity with SOSIP-stabilized gp140 Env. Also see Supplementary Data 6 and 7.
