Table 2 Random effects meta-analyses for associations of candidate predictors with suffering in adulthood

From: Childhood predictors of suffering in adulthood across 22 countries

Variable

RR (95% CI)

Estimated proportion of effects by threshold

I2

Global p value

<0.90

>1.10

Relationship with mother when growing up

Ā Ā Ā Ā 

0.000005

ā€ƒRef: Very bad/somewhat bad

–

–

–

–

Ā 

ā€ƒVery good/somewhat good

0.99 (0.96, 1.03)

0.00

0.05

32.4

Ā 

Relationship with father when growing up

Ā Ā Ā Ā 

0.000005

ā€ƒRef: Very bad/somewhat bad

–

–

–

–

Ā 

ā€ƒVery good/somewhat good

0.96 (0.94, 0.98)

0.00

0.00

19.2

Ā 

Family structure around age 12

Ā Ā Ā Ā 

0.000003

ā€ƒRef: Parents were married

–

–

–

–

Ā 

ā€ƒParents were divorced

1.06 (1.02, 1.11)

0.00

0.23

56.4

Ā 

ā€ƒParents were never married

1.02 (0.94, 1.10)

0.18

0.32

87.0

Ā 

ā€ƒOne or both parents had died

1.03 (0.98, 1.08)

0.00

0.18

36.4

Ā 

Subjective financial status of the family around age 12

Ā Ā Ā Ā 

0.000003

ā€ƒRef: Got by

–

–

–

–

Ā 

ā€ƒLived comfortably

0.94 (0.92, 0.97)

0.05

0.00

36.3

Ā 

ā€ƒFound it difficult

1.05 (1.02, 1.09)

0.00

0.23

56.3

Ā 

ā€ƒFound it very difficult

1.06 (1.01, 1.10)

0.00

0.32

50.1

Ā 

Experienced abuse when growing upa

Ā Ā Ā Ā 

0.000001

ā€ƒRef: No

–

–

–

–

Ā 

ā€ƒYes

1.27 (1.21, 1.33)

0.00

0.95

86.6

Ā 

Felt like an outsider in the family when growing up

Ā Ā Ā Ā 

0.000002

ā€ƒRef: No

–

–

–

–

Ā 

ā€ƒYes

1.20 (1.14, 1.26)

0.00

0.77

83.9

Ā 

Self-rated health when growing up

Ā Ā Ā Ā 

0.000001

ā€ƒRef: Good

–

–

–

–

Ā 

ā€ƒExcellent

0.85 (0.79, 0.91)

0.59

0.00

92.3

Ā 

ā€ƒVery good

0.90 (0.87, 0.93)

0.45

0.00

72.8

Ā 

ā€ƒFair

1.09 (1.05, 1.13)

0.00

0.41

57.1

Ā 

ā€ƒPoor

1.14 (1.07, 1.22)

0.00

0.50

73.4

Ā 

Immigration status

Ā Ā Ā Ā 

0.000007

ā€ƒRef: Born in this country

–

–

–

–

Ā 

ā€ƒBorn in another country

0.96 (0.89, 1.03)

0.32

0.18

65.2

Ā 

Frequency of religious service attendance around age 12

Ā Ā Ā Ā 

0.000006

ā€ƒRef: Never

–

–

–

–

Ā 

ā€ƒā‰„1/week

1.03 (0.97, 1.09)

0.05

0.23

78.9

Ā 

ā€ƒ1–3/month

1.05 (1.00, 1.10)

0.00

0.27

61.5

Ā 

ā€ƒ<1/month

1.01 (0.97, 1.05)

0.00

0.09

57.6

Ā 

Year of birth

Ā Ā Ā Ā 

0.000002

ā€ƒRef: 1998–2005 (current age: 18–24 years)

–

–

–

–

Ā 

ā€ƒ1993–1998 (current age: 25–29 years)

0.99 (0.95, 1.04)

0.18

0.09

65.4

Ā 

ā€ƒ1983–1993 (current age: 30–39 years)

0.99 (0.93, 1.06)

0.18

0.27

87.1

Ā 

ā€ƒ1973–1983 (current age: 40–49 years)

1.01 (0.92, 1.10)

0.27

0.27

92.6

Ā 

ā€ƒ1963–1973 (current age: 50–59 years)

1.05 (0.94, 1.16)

0.27

0.32

94.1

Ā 

ā€ƒ1953–1963 (current age: 60–69 years)

1.04 (0.90, 1.20)

0.27

0.27

95.5

Ā 

ā€ƒ1943–1953 (current age: 70–79 years)

1.07 (0.89, 1.28)

0.36

0.27

95.3

Ā 

ā€ƒ1943 or earlier (current age: 80+ years)

0.66 (0.20, 2.21)

0.23

0.45

99.8

Ā 

Gender

Ā Ā Ā Ā 

0.000002

ā€ƒRef: Male

–

–

–

–

Ā 

ā€ƒFemale

1.08 (1.04, 1.12)

0.00

0.36

83.2

Ā 

ā€ƒOther

0.39 (0.08, 1.98)

0.33

0.50

99.7

Ā 
  1. Estimated proportion of effects by threshold: the estimated proportion of effects across the implied distribution of effect sizes within the countries that are either less than a risk ratio of 0.90 or above a risk ratio of 1.10.
  2. I2: an estimate of the percent of variability in effect sizes that cannot be attributed to sampling variability.
  3. Global p value: a test of the null hypothesis that there is no association between the predictor and suffering in adulthood in all the countries.
  4. Additional heterogeneity metrics of the effects are provided in Supplementary Figs.Ā 1–27, along with the associated Q-statistics for the heterogeneity in the effects on the log(RR) scale.
  5. CI confidence interval, RR risk ratio.
  6. aMeta-analysis for experienced abuse when growing up only includes results for 21 countries because this question was not used in Israel. All p values passed the Bonferroni-corrected threshold of p < 0.0045 (p = 0.05/11).