Fig. 6: Contour-enhanced funnel plots for subgroups of metabolic change.

a increased cardiac fatty acid oxidation (FAO); b decreased cardiac FAO; c increased cardiac glucose oxidation (GO); d decreased FAO and increased cardiac GO. The plot shows the observed effect sizes against the corresponding inverse standard errors. Contours of significance are centred around null, and dotted pseudo 95% confidence interval (CI) guidelines are depicted around the random-effects pooled estimate.