Table 1 Significant effect of eQS on breast, cervical, and thyroid cancer risk

From: Germline genetic scores associated with cancer gene expression and immune responses across multiple cancer types

Cancer

eGene (OG/TSG)

eQTL

Chr:Position

Risk allele

βeQS a

OR (eQSgene) [95% CI] b

p (eQSgene) b

Breast

MAP3K1 (TSG)

rs80310238

5: 56267984

A

0.26

1.06 [1.04–1.08]

4.80E-13

IDH2 (OG)

rs2939847

15:90618867

T

0.15

1.03 [1.02-1.05]

3.42E-04

rs4553601

15:90647988

G

0.21

rs11073900

15:90648526

C

0.28

rs11073901

15:90649373

C

0.18

Cervix

PAX8 (OG)

rs6707386

2:113981022

G

0.32

1.09 [1.06-1.13]

1.85E-09

Thyroid

NRG1 (OG)

rs118092053

8:32142145

G

0.7

1.24 [1.15-1.34]

2.26E-08

rs7842287

8:32150388

G

0.25

rs10503908

8:32172201

A

0.33

rs7010701

8:32182131

G

0.5

rs10102632

8:32183433

A

0.5

rs7009436

8:32211452

A

0.36

rs11783991

8:32212920

G

0.31

rs9918832

8:32282597

C

0.28

rs11782671

8:32290601

T

0.25

rs7845525

8:32295728

C

0.34

rs35248458

8:32366447

T

0.34

rs17718751

8:32379719

T

0.48

rs6651144

8:32382668

T

0.35

rs3934585

8:32397085

G

0.4

rs10100620

8:32417507

G

0.26

rs13258892

8:32423537

C

0.53

rs73234160

8:32427400

G

0.33

rs2466101

8:32427647

G

0.43

rs2439304

8:32430371

A

0.67

rs2466096

8:32430732

A

0.62

rs2466064

8:32441203

A

0.32

  1. eGene, genes whose expression levels are associated with eQTL; eQTL, expression quantitative trait loci; Chr:Position, Chromosome: Base Position (GRCh37); βeQS, beta of eQS; OR, odds ratio; CI, confidence interval; eQSgene, eQTL-specific genetic score per gene.
  2. a beta of eQS = beta of eQTL × (−1) (if genes are TSG), as described in Methods.
  3. b OR (eQSgene) was estimated by a multivariable logistic regression model with cancer PRS adjusted by covariates. P-value was obtained by the Wald test for each model.
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