Fig. 4: Theoretical vaccine coverage for extra-intestinal pathogenic E. coli 9-valent (EXPEC9V) and EXPEC4V. | Communications Medicine

Fig. 4: Theoretical vaccine coverage for extra-intestinal pathogenic E. coli 9-valent (EXPEC9V) and EXPEC4V.

From: High diversity of Escherichia coli causing invasive disease in neonates in Malawi poses challenges for O-antigen based vaccine approach

Fig. 4

a Rarefaction curve showing the theoretical protection given against vaccines covering the most frequently isolated H-types and O-types, as well as the potential protection given by the EXPEC9V and EXPEC4V. The horizontal line shows the point at which 80% of isolates would be covered. For isolates with more than one H-type both were counted, there were multiple isolates with more than one H-type so the line for H-type goes above 1. Supplementary Fig. 3 shows the same graph but where isolates had more than one H-type called they were only counted once. b A bar chart showing the frequency of the different O-types with the O-types covered by EXPEC4V and the additional coverage on top of this offered by EXPEC9V highlighted. c A bar chart showing the proportion of isolates per year that had different O-types. The colours are the same as those represented in (b).

Back to article page