Fig. 4: Mediation effects of inflammation-related markers on the association between IMD and ASCVD risk adjusting for age and BMI.

β1 represents the association between the exposure (IMD) and inflammatory markers with a 95% CI. β2 represents the association between inflammatory markers and ASCVD score with a 95% CI. β represents the total effect of the exposure (IMD) on the ASCVD score with a 95% CI. VAF: Variance Account For. P indicates the significance of the indirect effect of mediated protein markers.