Fig. 6: Survival analysis of tRF-targeted metabolic pathways.

a Kaplan-Meier survival curve illustrating the prognostic significance of genes enriched in overall metabolic pathways. Dashed lines indicate the median survival threshold, corresponding to a 50% survival probability for the respective patient cohorts at specific time points. The tables below the plot display the number of patients at risk over the observation period. Statistical significance was determined using the log-rank test. HR hazard ratio, CI confidence interval. b KEGG pathway enrichment analysis identifying specific metabolic pathways associated with the enriched genes. Statistical significance is indicated by a p-value scale ranging from 0.05 (light green) to 0.01 (gray). c–f Kaplan-Meier survival curves comparing high-risk and low-risk groups based on pathway activity scores for key metabolic pathways, including biosynthesis of cofactors, purine metabolism, oxidative phosphorylation, and alanine, aspartate, and glutamate metabolism. Dashed lines represent the median survival threshold, corresponding to a 50% survival probability for the respective patient cohorts at specific time points. The tables below each plot show the number of patients at risk over the observation period. Statistical significance was determined using the log-rank test. HR hazard ratio, CI confidence interval.