Fig. 4: Genetic variants associated with GOS core module. | Communications Medicine

Fig. 4: Genetic variants associated with GOS core module.

From: Molecular profiles of the great obstetrical syndromes reveal common features and dynamic changes in early pregnancy

Fig. 4

a Manhattan plot of genome-wide significant SNPs associated with the eigenprotein of the turquoise protein module. The horizontal red line represents a P-value of 5 ×10-6. Analysis was performed on data from n  =  313 study participants with both proteomic and genotyping information. b Integration of the hub proteins in the GOS core module and the genomic signatures identified through genome-wide association study and candidate gene association study via protein-protein interaction network. Green nodes represent the genomic signatures. Red, orange and yellow nodes represent GOS hub proteins, with darker colors corresponding to higher betweenness centrality values and larger nodes corresponding to higher degree centrality values. Grey nodes represent the nodes necessary to connect the seed nodes (genomic signatures and GOS hub proteins) in a minimum interaction network. GOS great obstetrical syndromes.

Back to article page