Fig. 1: Nine Enterobacter isolates carrying mcr-9 and mcr-10 from bloodstream infections in Dartmouth-Hitchcock Medical Center, New Hampshire, USA. | Communications Medicine

Fig. 1: Nine Enterobacter isolates carrying mcr-9 and mcr-10 from bloodstream infections in Dartmouth-Hitchcock Medical Center, New Hampshire, USA.

From: Dissemination dynamics of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones

Fig. 1

a A maximum likelihood phylogenetic tree based on 573,405 single nucleotide polymorphisms (SNP) extracted from the 2.99 Mb sequence alignment of 3022 core genes. The tree is rooted at the midpoint. Tree scale indicates the number of nucleotide substitutions per site. Colored strips next to the tree show the Enterobacter species, sequence type (ST), year of isolation, and mcr gene variants. The distribution of different plasmid replicon types is indicated by the green (present) or white (absent) circles. b Genetic neighborhood of mcr-9.1 detected in chromosomes (EXB47 and EXB59) and plasmids (pEXB40_2 and pEXB45_1). Genes are represented by arrows. Colors of arrows represent different functions, with the same colors indicating homologous genes. Grayscale strips connecting the arrows from different cellular locations represent the sequence similarity (%) between them. Only those regions with 80 – 100% sequence similarity are shown. Genomic characteristics of the nine Enterobacter isolates are presented in Supplementary Data 3. Features of the plasmid assemblies are presented in Supplementary Data 4.

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