Table 1 Associations of sex-specific VAT quartiles with carotid wall volume (mm3) in the CAHHM cohort

From: Visceral adipose tissue and hepatic fat as determinants of carotid atherosclerosis

 

Carotid Wall Volume, mm3 in Visceral Adipose Quartiles

 
 

Q1

Q2

Q3

Q4

P-trend

Overall (N = 5546)

     

N

1428

1401

1397

1320

 

No fixed covariates

897.6 (876.8, 918.4)

907.4 (886.6, 928.2)

907.0 (886.2, 927.9)

917.8 (896.9, 938.8)

0.003

Minimally adjusted

899.3 (877.7, 921.0)

902.8 (881.2, 924.5)

903.9 (882.3, 925.6)

911.7 (890.0, 933.5)

0.05

+ IHRS

900.1 (878.7, 921.5)

903.1 (881.8, 924.4)

903.7 (882.4, 925.0)

910.6 (889.0, 932.2)

0.12

+HFF

899.5 (877.7, 921.3)

902.8 (881.3, 924.4)

903.9 (882.4, 925.4)

911.4 (889.3, 933.5)

0.12

Minimal + IHRS without WHR

900.1 (878.5, 921.7)

903.6 (882.0, 925.1)

904.6 (883.0, 926.2)

912.4 (890.6, 934.2)

0.06

Females (N = 3054)

N

800

749

772

733

 

No fixed covariates

837.4 (815.5, 859.2)

843.8 (821.7, 865.8)

844.8 (822.8, 866.8)

848.1 (826.0, 870.2)

0.14

Minimally adjusted

842.9 (821.3, 864.5)

844.5 (822.8, 866.1)

842.9 (821.3, 864.5)

843.6 (821.9, 865.3)

0.99

+ IHRS

844.5 (822.8, 866.2)

845.4 (823.7, 867.0)

843.1 (821.6, 864.7)

841.9 (819.9, 863.8)

0.69

+HFF

843.6 (821.8, 865.4)

844.9 (823.3, 866.5)

843.5 (822.1, 865.0)

843.7 (821.3, 866.1)

0.97

Minimal + IHRS without WHR

844.0 (822.4, 865.6)

845.1 (823.4, 866.7)

843.1 (821.5, 864.6)

842.5 (820.7, 864.4)

0.80

Males (N = 2492)

N

628

652

625

587

 

No fixed covariates

966.6 (943.4, 989.9)

973.3 (950.1, 996.4)

977.0 (953.6, 1000)

996.8 (973.0, 1021)

0.003

Minimally adjusted

967.6 (945.2, 990.1)

973.7 (951.6, 995.8)

976.5 (954.2, 998.8)

993.2 (970.5, 1016)

0.01

+ IHRS

968.0 (945.4, 990.6)

973.8 (951.7, 995.8)

976.2 (953.9, 998.6)

992.6 (969.4, 1016)

0.03

+HFF

967.3 (944.2, 990.5)

973.4 (951.3, 995.5)

976.4 (954.0, 998.7)

993.1 (969.3, 1017)

0.04

Minimal + IHRS without WHR

967.3 (944.7, 989.9)

973.6 (951.4, 995.7)

976.7 (954.3, 999.1)

993.8 (970.7, 1017)

0.01

  1. Data within each cell are the adjusted least-squared means derived from a mixed model using all participants falling into that sex-specific quartile of VAT. Each mean and (95% confidence interval) is adjusted for the covariates presented in the first column. The minimally adjusted model contains a random effect for centre; as well as fixed effects for age and ethnicity. A linear contrast was used to assess the P-trend, using values of 1–4 across the quartiles. P- sex interaction > 0.28.
  2. VAT visceral adipose tissue, IHRS INTERHEART Risk Score, HFF hepatic fat fraction, WHR waist-to-hip ratio.
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