Fig. 4: Single-cell RNAseq data confirm the relations between ARIADNE/cytokine score and pCR.
From: Predicting the response to immunotherapy from gene expression data in HER2-negative breast cancer
a Schematic of the NCT03366844 trial. b ARIADNE score measured in cancer cells is significantly associated with pCR (p < 10−4). The cytokine scores measured in (c) cancer cells and (d) CAF is significantly associated with pCR. e The relation between the ARIADNE, measured in CANCER cells, and the cytokine score, measured in CAF, shows that the highest pCR rates are found for ARIADNE low and cytokine high. Each dot corresponds to scores aggregated over each individual patient. f Temporal variation of the ARIADNE score for patients with or without pCR. Temporal variations of the cytokine score for (g) CAF and (h) cancer cells. Time variations in (f, g, h) are small but statistically significant (p < 10−4). Results based on DATA2, see methods. In boxplots, the box is bounded by the first and third quartiles with whiskers representing 1.5 times the interquartile range.
