Fig. 3: Odds ratios (ORs) and 95% confidence intervals (CIs) for long-term opioid use (>3 months) (reference: short-term use defined as ≤3 months).

Abbreviations: CI confidence interval, OR odds ratio. n = 754 982 opioid-naïve individuals included in the analysis. Health care-related characteristics are based on diagnoses in period prior to initial prescription: 1-year history of cancer, 3-month history of an external injury, and 5-year history of substance use disorders and number of psycholeptic medications. History of prescription psycholeptic drug use is a proxy for number of common psychiatric disorders.