Fig. 4: Chromosomal hotspots for integration.
From: Early pandemic HIV-1 integration site preferences differ across anatomical sites
a Comparison of the percentage of total integration sites located within 100 bp of each other (‘hotspots’). Statistical comparisons are made with respect to the brain. Significant differences are denoted by asterisks; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) (Chi-square test with Yates’ correction). b Comparison of the percentage of total integration sites (numbers inside boxes on the heatmap) on each chromosome within each tissue. Blue shading represents the normalized number of integration sites per chromosome length. c Schematic showing the approximate locations of integration site hotspots on chromosome 9 from the brain. If integration hotspots are located within a gene, the gene name is provided adjacent to the integration site cluster. d Circos plot showing the approximate locations of integration site hotspots on each chromosome from each tissue.
