Fig. 6: HIV-1 LTR heterogeneity at the TBC1D5 integration site hotspot.
From: Early pandemic HIV-1 integration site preferences differ across anatomical sites
a Network visualization representing the sequence heterogeneity among 1289 HIV-1 LTR sequences, focusing on the last 29 bp of the HIV-1 3’ LTR region. Each node corresponds to an individual LTR sequence, while edges indicate pairwise nucleotide differences, with edge weight and color intensity reflecting the degree of divergence. Highly similar sequences form distinct clusters, while more divergent sequences exhibit fewer connections, suggesting independent integration events. b Sequence logo depicting the nucleotide conservation and variability across the last 29 nucleotides of the HIV-1 LTR region. The height of each nucleotide at a given position represents its relative frequency, with taller letters indicating higher conservation. c Overlapping integration sites at the TBC1D5 integration site hotspot (chr3:17443680) in independent integration site datasets available from the Retrovirus Integration Database (v2.0).
