Table 1 Baseline characteristics of all included patients and stratified by training and test dataset

From: An interpretable machine learning algorithm enables dynamic 48-hour mortality prediction during an ICU stay

 

All

Training dataset

Test dataset

n = 9786

n = 4892

n = 4894

Demographics and medical history

Age (years), median (IQR)

66 (55–77)

67 (55–76)

66 (56–77)

Sex, No. (%)

Female

3879 (39.6)

1941 (39.7)

1938 (39.6)

Male

5907 (60.4)

2951 (60.3)

2956 (60.4)

BMI (kg/m2), median (IQR)

26.1 (23.5–29.4)

26.1 (23.5–29.4)

26.1 (23.5–29.4)

Diabetes, No. (%)

3300 (33.7)

1657 (33.9)

1643 (33.6)

Hypercholesterolemia, No. (%)

936 (9.6)

483 (9.9)

453 (9.3)

Arterial hypertension, No. (%)

3595 (36.7)

1819 (37.2)

1776 (36.3)

Chronic kidney disease (any stage), No. (%)

2700 (27.6)

1347 (27.5)

1353 (27.6)

Renal replacement therapy, No. (%)

1454 (14.9)

694 (14.2)

760 (15.5)

NIV/IMV, No. (%)

4680 (47.8)

2368 (48.4)

2322 (47.4)

Main diagnosis1, No. (%)

Diseases of the digestive system

835 (8.5)

414 (8.5)

421 (8.6)

Diseases of the nervous system

250 (2.6)

129 (2.6)

121 (2.5)

Injury, poisoning and certain other consequences of external causes

1065 (10.9)

529 (10.8)

536 (11.0)

Certain infectious and parasitic diseases

365 (3.7)

173 (3.5)

192 (3.9)

Diseases of the circulatory system

3315 (33.9)

1669 (34.1)

1646 (33.6)

Neoplasms

1630 (16.7)

834 (17.0)

796 (16.3)

Diseases of the respiratory system

1235 (12.6)

607 (12.4)

628 (12.8)

Diseases of the genitourinary system

270 (2.8)

122 (2.5)

148 (3.0)

Other

821 (8.4)

414 (8.5)

406 (8.3)

Admission category, No. (%)

Medical

4420 (45.2)

2217 (45.3)

2203 (45.0)

Scheduled surgery

784 (8.0)

385 (7.9)

399 (8.2)

Unscheduled surgery

3362 (34.4)

1669 (34.1)

1693 (34.6)

Other

1220 (12.5)

621 (12.7)

599 (12.2)

Admission source, No. (%)

Emergency Room

3031 (31.0)

1546 (31.6)

1485 (30.3)

Other ICU

2247 (23.0)

1123 (23.0)

1124 (23.0)

Hospital ward

3152 (32.2)

1556 (31.8)

1596 (32.6)

External hospital

887 (9.1)

431 (8.8)

456 (9.3)

Other

469 (4.8)

236 (4.8)

233 (4.8)

Length of ICU stay

1 day, No. (%)

3032 (31.0)

1500 (30.7)

1509 (30.8)

2 days, No. (%)

1589 (16.2)

797 (16.3)

792 (16.2)

≥ 3 days, No. (%)

5165 (52.8)

2595 (53.0)

2570 (52.5)

Length of ICU stay (days), median (IQR)

3.3 (1.8–8.0)

3.3 (1.8–8.0)

3.2 (1.8–8.0)

Mortality, No. (%)

ICU mortality

1528 (15.6)

740 (15.1)

788 (16.1)

In-hospital mortality

2684 (27.4)

1338 (27.4)

1346 (27.5)

  1. BMI body mass index. ICU intensive care unit. IQR interquartile range. IMV invasive mechanical ventilation. NIV noninvasive ventilation.
  2. 1According to ICD-10 code, International Classification of Diseases codes, 10th revision, German modification.