Fig. 5: Scope of the N-difluoroalkylative dearomatization with imines, alkenes and alkynes. | Nature Synthesis

Fig. 5: Scope of the N-difluoroalkylative dearomatization with imines, alkenes and alkynes.

From: In silico reaction screening with difluorocarbene for N-difluoroalkylative dearomatization of pyridines

Fig. 5

a, Reaction realization and scope of imines based on the AFIR prediction for the reaction of two molecules of methanimine and difluorocarbene. b, Reaction realization and scope of alkenes based on the AFIR prediction for the reaction of methanimine, ethylene and difluorocarbene. c, Reaction realization and scope of alkynes based on the AFIR prediction for the reaction of methanimine, acetylene, and difluorocarbene. Reactions were performed under the conditions shown in each section. Isolated yields are given in all cases. The ratios of endo- to exo-isomers were measured using 1H NMR spectroscopic analysis, and the endo-form of 41 was confirmed using NOE analysis. n.d., not detected.

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