Fig. 2: Design of the catalytic oligomerization template.
From: Catalytic length-controlled oligomerization with synthetic programmable templates
a, Structure of the envisioned macrocycles for templated catalysis with catalytic sites in blue and green, and hydrazone linkage in brown. b, General structure of oligoprolines with azidoproline residues in every third position (top) and model of a PPII-helical 12-mer (bottom). c, Bioinspired decarboxylative aldol-type reaction catalysed by bifunctional catalysts bearing thiourea and amine moieties (left) and plausible activation mode (right). Note that activation is also possible by iminium ion formation and reverse coordination of substrates to the catalytic sites. d, Bifunctional substrate for templated oligomerization.
