Fig. 1: Reaction design and development.
From: Synthesis of non-equivalent diamides and amido-esters via Pd-catalysed carbonylation
a, Selected examples of biologically active molecules and pharmaceuticals featuring diamide and amido-ester skeletons. b, Traditional ways of synthesizing non-symmetrical diamides c, An example for preparation of non-symmetrical terephthaldiamides, over six synthetic steps19. d, General concept for conversion of a chemical toolbox to heterobifunctional molecules through link chemistry. e, The method reported in the present study to access non-symmetrical diamides and amido-esters through dicarbonylation reactions.
