Table 4 Selective synthesis of amido-esters by Pd-catalysed dicarbonylation reactions

From: Synthesis of non-equivalent diamides and amido-esters via Pd-catalysed carbonylation

  1. Standard reaction conditions: 1 (0.2 mmol), 2 (0.2 mmol), 5 (0.6 mmol), Pd(MeCN)2Cl2 (2.5 mol%), L14 (10 mol%), Na2HPO4 (10 mol%), CH2Cl2 (2.0 ml), CO (40 bar), 20 h at 60 °C. Isolated yields are given within parentheses. NMR spectroscopic yields (values before parentheses) and z:e-selectivities of 6 were determined by crude 1H NMR analysis using dibromomethane as an internal standard. Unless otherwise noted, e:z > 20/1 in all cases. a2 (0.3 mmol); 5 (0.3 mmol). b5 (0.2 mmol). cDisplacement ellipsoid plot (30% probability level) of one molecule of the asymmetrical unit of 6abd (without H).
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