Amine–borane adducts activate alkyl halides via halogen-atom transfer through boryl radical intermediates, enabling the formation of C(sp2)–C(sp3) bonds using either organometallic reagents or organic halides.
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09 July 2024
A Correction to this paper has been published: https://doi.org/10.1038/s44160-024-00617-2
References
de Meijere, A. & Diederich, F. (eds) Metal-Catalyzed Cross-Coupling Reactions (Wiley-VCH, 2004).
Ruiz-Castillo, P. & Buchwald, S. L. Chem. Rev. 116, 12564–12649 (2016).
Beutner, G. L. et al. J. Org. Chem. 86, 10380–10396 (2021).
Dombrowski, A. W. et al. ACS Med. Chem. Lett. 11, 597–604 (2020).
Chan, A. Y. et al. Chem. Rev. 122, 1485–1542 (2022).
Juliá, F., Constantin, T. & Leonori, D. Chem. Rev. 122, 2292–2352 (2022).
Chatgilialoglu, C., Ferreri, C., Landais, Y. & Timokhin, V. I. Chem. Rev. 118, 6516–6572 (2018).
Caiger, L., Zhao, H., Constantin, T., Douglas, J. J. & Leonori, D. ACS Catal. 13, 4985–4991 (2023).
Sachidanandan, K., Niu, B. & Laulhé, S. ChemCatChem 15, e202300860 (2023).
Zhang, Z., Tilby, M. J. & Leonori, D. Nat. Synth. https://doi.org/10.1038/s44160-024-00587-5 (2024).
Zhang, Z., Górski, B. & Leonori, D. J. Am. Chem. Soc. 144, 1986–1992 (2022).
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Rodrigalvarez, J., Martin, R. Boryl radicals facilitate C(sp2)–C(sp3) cross-coupling reactions. Nat. Synth 3, 1188–1189 (2024). https://doi.org/10.1038/s44160-024-00586-6
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DOI: https://doi.org/10.1038/s44160-024-00586-6
