Fig. 4: Scope for the pyridine-to-benzonitrile replacement.
From: A three-step strategy for the conversion of pyridines into benzonitriles
a, Pyridine scope. b, Tandem pyridine deconstruction–amination–Diels–Alder reactivity to give ortho-aminated benzonitriles. [Yield of step 1 (ring opening), yield of step 2 (cycloaddition)]. Superscripts A and B indicate reactions performed using conditions A and B (see Fig. 2 for details); for details of superscript C, see Supplementary Information. TBS, tert-butyldimethylsilyl; Ts, p-toluenesulfonyl; Boc, tert-butoxycarbonyl.
