A method for the synthesis of oligosulfonimidates with control of the monomer sequence and the stereogenicity at each of the S(VI) atoms is demonstrated. This approach hinges on the use of robust and enantiospecific sulfur–fluoride and sulfur–phenolate exchange reactions and also allows for the efficient synthesis of chiral sequence-controlled polymers.
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References
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This is a summary of: Han, Y. et al. Synthesis of chiral sequence-defined oligomers via sulfur–fluoride and sulfur–phenolate exchange reactions. Nat. Synth. https://doi.org/10.1038/s44160-025-00805-8 (2025).
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Synthesis of oligomers with control of the monomer sequence and chirality. Nat. Synth 4, 1031–1032 (2025). https://doi.org/10.1038/s44160-025-00806-7
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DOI: https://doi.org/10.1038/s44160-025-00806-7
