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Coupling reactions for the growth of covalent organic frameworks

Nature Synthesis volume 5, pages 158–159 (2026)Cite this article

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The synthesis of covalent organic frameworks — a class of crystalline porous polymer — has been limited to reversible polycondensation reactions, whereas irreversible coupling reactions have typically yielded amorphous materials. Now, a micro-interfacial polymerization method is developed that uses the Glaser–Eglinton coupling reaction to synthesize covalent organic frameworks.

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Fig. 1: COFs synthesized through Glaser–Eglinton coupling reactions.

References

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This is a summary of: Li, Z. et al. Synthesis of covalent organic frameworks via coupling polymerization. Nat. Synth. https://doi.org/10.1038/s44160-025-00895-4 (2025).

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Coupling reactions for the growth of covalent organic frameworks. Nat. Synth 5, 158–159 (2026). https://doi.org/10.1038/s44160-025-00926-0

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