Extended Data Fig. 8: The effect of dextromethorphan on Timothy syndrome mouse model.
From: Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome
(a) Plasma dextromethorphan (Dxm) concentrations in control mice at day 4 and day 11 after continuous dosing of Dxm in drinking water (n = 13, mean ± s.e.m.). Dxm was provided in water since day 1 at 8am. * 8 p.m. time point at day 4 had an outlier defined by statistics and the outlier was excluded from the final analysis. (b) Representative analysis procedures for ECG traces in Timothy syndrome (TS) mice without treatment or treated with Dxm at day 4 (also used in Fig. 5c,d). (c) QT intervals were significantly shortened by Dxm treatment in TS mice at day 11 (n = 8 for ctrl, n = 4 for TS, n = 7 for TS + Dxm, female, 12-week old). Three mouse heart samples from each group were used for the global proteomics analysis. All data of Extended Data Fig. 8 are mean ± s.d. except Extended Data Fig. 8a. One-way ANOVA with Tukey’s multiple comparisons were used for statistics. ** P < 0.01, n.s., not significant.
