ABCA1 promotes the efflux of cholesterol from cells to HDL and has anti-atherogenic activities. Sun and Li present cryo-EM structures of ABCA1 in the ATP-free and ATP-bound states, which reveal bound cholesterol molecules and suggest a transmembrane cholesterol-transport mechanism.
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References
Wang, N., Lan, D., Chen, W., Matsuura, F. & Tall, A. R. Proc. Natl Acad. Sci. USA 101, 9774–9779 (2004).
Timmins, J. M. et al. J. Clin. Invest. 115, 1333–1342 (2005).
Qian, H. et al. Cell 169, 1228–1239.e1210 (2017).
Sun, Y. & Li, X. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00022-y (2022).
Sun, Y. et al. Proc. Natl Acad. Sci. USA 118, e2110483118 (2021).
Tarling, E. J. & Edwards, P. A. Biochim. Biophys. Acta 1821, 386–395 (2012).
Scortecci, J. F. et al. Nat. Commun. 12, 5902 (2021).
Wang, N., Silver, D. L., Costet, P. & Tall, A. R. J. Biol. Chem. 275, 33053–33058 (2000).
Phillips, M. C. J. Lipid Res. 59, 749–763 (2018).
Rohatgi, A. et al. N. Engl. J. Med. 371, 2383–2393 (2014).
Groenen, A. G., Halmos, B., Tall, A. R. & Westerterp, M. Crit. Rev. Biochem. Mol. Biol. 56, 426–439 (2021).
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A.T. is a scientific founder of 1016 Bio, and is on the scientific advisory board of Staten Biotechnologies and Beren Therapeutics.
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Tall, A.R., Wang, N. New insights into cholesterol efflux via ABCA1. Nat Cardiovasc Res 1, 198–199 (2022). https://doi.org/10.1038/s44161-022-00036-6
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DOI: https://doi.org/10.1038/s44161-022-00036-6
