Extended Data Fig. 7: AAV-BI30 efficiently transduces the brain’s largest arteries.
From: A high-efficiency AAV for endothelial cell transduction throughout the central nervous system
AAV-BI30:CAG-NLS-GFP-miR122-WPRE was intravenously administered to an adult C57BL/6 mouse at 5 × 1011 vg/animal and transduction was assessed after 3 weeks. Robust, endothelial-specific transduction was observed throughout the cerebral arteries, Circle of Willis, and the head of the basilar artery. Scale bar shown is 100 μm. Images are representative of n = 1 mouse.
