Extended Data Fig. 6: Natriuretic peptide pathway analyses.

Heatmap of associations with SNPs in genes of the natriuretic peptide pathway. All cardiac imaging traits and traits with a genome-wide significant association with rs1173727 (NPR3) were included. SNPs were included if they have a genome-wide significant association with one of these traits except height (height is an extremely polygenic trait with many genome-wide association signals). Values indicate -log10(P-value) of the association test (BOLT-LMM, linear mixed-model, 2-sided, not corrected for multiple comparisons), directionality is aligned to the beta values of the systolic blood pressure (sbp_adj) associations, and to the height associations if there is no significant blood pressure association. AAo, ascending aorta; DAo, descending aorta; DBP, diastolic blood pressure; Ecc, circumferential strain; EDV, end diastolic volume; EF, ejection fraction; Ell, longitudinal strain; Err, radial strain; ESV, end-systolic volume; FVC, forced vital capacity; LA, left atrium; LV, left ventricle; LVM, left ventricular mass; PDSR, peak diastolic strain rate; RA, right atrium; RV, right ventricle, SBP, systolic blood pressure; SV, stroke volume.