Fig. 5: Significant associations of the polygenic instrumental variable scores for diastolic function traits with UK Biobank phenotypes.
From: Genetic and environmental determinants of diastolic heart function
a, Quantitative traits that significantly associated with the PIVSs of diastolic function (beta coefficient point estimates standardized to change per 1 s.d. increase in diastolic function trait with 95% CI). b, Binary traits that significantly associated with the PIVSs of diastolic function. Point estimates are log(odds ratio) per 1 s.d. increase in diastolic function trait (95% CI). Detailed results, including numerical P values and 95% CI are shown in Supplementary Fig. 10. One unit change in the PIVS represents a change of 1 s.d. in the respective diastolic function trait. All dependent variables (traits) were standardized, representing the change in dependent variable s.d. for a 1 × s.d. change in the respective measurement. Associations not significant after multiple testing correction (conducted per PIVS) are displayed as gray bars. LDL, low-density lipoprotein; HDL. high-density lipoprotein; IGF-1, insulin-like growth factor 1; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; eGFR, estimated glomerular filtration rate; DBP, diastolic blood pressure; NS, non-significant. n = 449,263.
