Fig. 6: Dynamic meshes defining the full spatiotemporal domain of heart tube morphogenesis.
a, Elaboration of a continuous sequence using the MSG shapes. The process starts by mapping the mesh connectivity from the first time point to the next shape. This process is repeated until the connectivity of the first mesh is propagated until the final mesh at t10. This process can also be applied using the RSG shapes. b, Concept of shape interpolation applied to the three first time points of the RSG shapes. Each row shows the result for the different tissues forming the pericardial cavity. The dots depicted on top of the myocardium shape illustrate the position of a single vertex traveling through the shapes as morphogenesis progresses. c, The plot illustrates the estimated trajectory of the vertex highlighted in b; myo, myocardium; spl, splanchnic mesoderm; som, somatic mesoderm; par, paraxial mesoderm. d, Temporal reference for morphological and physiological events during heart tube formation. Data on the onset of contraction/beating and real-time scale were obtained from in vitro live-imaging videos50; HT, heart tube; RV, right ventricle.
