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CARDIAC METABOLISM

Deciphering metabolic remodeling of the failing hearts

Nature Cardiovascular Research volume 1, pages 800–801 (2022)Cite this article

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A landscape view of metabolic remodeling in end-stage human failing hearts generated by multiomics analysis confirms main changes in cardiac energy metabolism and challenges several widely held mechanisms derived from animal models. Further validation in non-end-stage heart failure and metabolic flux analysis will be necessary to move the field forward.

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Fig. 1: Metabolic remodeling revealed in the failing heart.

References

  1. Ingwall, J. S. & Weiss, R. G. Circ. Res. 95, 135–145 (2004).

    Article  CAS  Google Scholar 

  2. Lopaschuk, G. D. et al. Circ. Res. 128, 1487–1513 (2021).

    Article  CAS  Google Scholar 

  3. Flam, E. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00117-6 (2022).

  4. Finck, B. N. & Kelly, D. P. Circulation 115, 2540–2548 (2007).

    Article  Google Scholar 

  5. Finck, B. N. & Kelly, D. P. J. Mol. Cell. Cardiol. 34, 1249–1257 (2002).

    Article  Google Scholar 

  6. Wallhaus, T. R. et al. Circulation 103, 2441–2446 (2001).

    Article  CAS  Google Scholar 

  7. Murashige, D. et al. Science 370, 364–368 (2020).

    Article  CAS  Google Scholar 

  8. Zhang, L. et al. Circ. Heart Fail. 6, 1039–1048 (2013).

    Article  CAS  Google Scholar 

  9. Schroeder, M. A. et al. Eur. J. Heart Fail. 15, 130–140 (2013).

    Article  CAS  Google Scholar 

  10. Cluntun, A. A. et al. Cell Metab. 33, 629–648 (2021).

    Article  CAS  Google Scholar 

  11. Kadkhodayan, A., Coggan, A. R. & Peterson, L. R. Heart Fail. Rev. 18, 567–574 (2013).

    Article  CAS  Google Scholar 

  12. Zhou, B. et al. J. Clin. Invest. 132, e155333 (2022).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work is in part supported by grants from the National Institute of Health (grant nos. HL110349, HL129510, HL142628, HL149695 and HL144937 to R.T.), Japan Heart Foundation (The 33th Bayer Yakuhin Research Grant Abroad to A.Y.), the Uehara Memorial Foundation (grant no. 202040002 to A.Y.) and the American Heart Association (grant no. 827259 to A.Y.).

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  1. Mitochondria and Metabolism Center, University of Washington, Seattle, WA, USA

    Akira Yoshii & Rong Tian

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  1. Akira Yoshii
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  2. Rong Tian
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Correspondence to Rong Tian.

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The authors declare no competing interests.

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Yoshii, A., Tian, R. Deciphering metabolic remodeling of the failing hearts. Nat Cardiovasc Res 1, 800–801 (2022). https://doi.org/10.1038/s44161-022-00118-5

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