Fig. 5: Pharmacological sGC stimulation influences leukocyte recruitment, atherosclerotic plaque formation and vascular inflammation.
a, Adoptive transfer of GFP+ leukocytes: study scheme, flow cytometry plot (left) and quantification (right) of GFP+ cells (n = 8 independent animals). b, Aortic root atherosclerotic plaques in Ldlr−/− mice that were fed a Western diet for 10 weeks containing 0 (control group, n = 9) or 150 ppm BAY-747 (n = 7). c, CD11b+ area of aortic roots in mice from the control (n = 11) and treatment groups (n = 8). d, Quantification of vascular inflammation by flow cytometry analysis of aortic cell suspensions of mice in the control (n = 12) and treatment groups (n = 12). Each symbol represents one independent mouse. Two-sided unpaired t-test. Data are the mean ± s.e.m. One outlier was removed in d in the analysis of neutrophils (150 ppm; n = 11) according to the ROUT test.
