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Genetic risk factors

Genetic causes and cardiovascular consequences of clonal hematopoiesis in the UK Biobank

Nature Cardiovascular Research volume 2, pages 13–15 (2023)Cite this article

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Pioneering cohort studies including the Framingham Heart Study have led to major insights into cardiovascular disease. However, these studies are underpowered to identify the effects of less common risk factors on human health. This has motivated the development of the UK Biobank, a biomedical database linking health and genetic information in 500,000 individuals.

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Fig. 1: CH is associated with health outcomes across many organ systems.

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Authors and Affiliations

  1. Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA

    J. Scott Beeler

  2. Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    Alexander G. Bick

  3. Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA

    Kelly L. Bolton

Authors
  1. J. Scott Beeler
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  2. Alexander G. Bick
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  3. Kelly L. Bolton
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Correspondence to Kelly L. Bolton.

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The authors declare no competing interests.

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Beeler, J.S., Bick, A.G. & Bolton, K.L. Genetic causes and cardiovascular consequences of clonal hematopoiesis in the UK Biobank. Nat Cardiovasc Res 2, 13–15 (2023). https://doi.org/10.1038/s44161-022-00198-3

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